A review article was just published in Nature Communications (https://doi.org/10.1038/s41467-025-60016-9) focusing on the industrial applicability of enzymatic and whole-cell processes for the utilization of C1 building blocks coauthored by Prof. Uwe Bornscheuer, Dr. Thomas Bayer and Ina Somvilla. They review how single and multi-enzyme transformations, natural C1-trophic microorganisms, and organisms with transplanted synthetic C1 assimilation pathways can synergize to strengthen the competitiveness of C1-based biomanufacturing.