The ribosome is one of the main antibiotic targets in the bacterial cell. Structures of naturally produced antibiotics and their semi-synthetic derivatives bound to ribosomal particles have provided unparalleled insight into their mechanisms of action, and they are also facilitating the design of more effective antibiotics for targeting multidrug-resistant bacteria. In this presentation, I will discuss the recent structural insights into the mechanism of action of ribosome-targeting antibiotics and the molecular mechanisms of bacterial resistance, in addition to the approaches that are being pursued for the production of improved drugs that inhibit bacterial protein synthesis.
Daniel Wilson made his PhD in Biochemistry at the University of Otago, Dunedin, New Zealand. Currently he is W3-Professor for Biochemistry at the Institute for Biochemistry and Molecular Biology at the University of Hamburg.
Moderation Professor Dr. Michael Hecker
